Generalized and mucosal melanosis associated with ultra-late recurrence of malignant melanoma.

We describe a patient with progressive hyperpigmentation of the skin and gas-trointestinal melanosis. The pigmented lesions in the stomach and duodenum served as a diagnostic sign of recurrent disease, 26 years after excision of melano-ma of the skin. A barium swallow and gastroduodenos-copy were performed in a healthy 63-year-old man who had been suffering from vague abdominal symptoms for a few months. Multiple flat and polypoid pigmented lesions, varying from brown to black, were observed in the stomach and duodenum (Figures 1, 2). A malignant melanoma had been excised from his neck 26 years previously. The new biopsies from the pigmented lesions in the upper gastrointestinal tract showed only melanotic pigment within macrophages and no malignant cells were found. Staining with S-100 and HMB-45 was negative. On examination, no suspected pigmented nevi were detected on the skin or mucous membranes. Normal fundoscopy and rec-toscopy findings ruled out the possibility of intraocular or anal melanoma. The results of a computed tomography scan showed diffuse liver metastasis, and some thickening of the gastric wall at the fundic area. A liver biopsy confirmed the diagnosis of metastatic malignant mela-noma. At 2 months later the patient noticed darkening of the skin, especially in exposed areas, and voided dark urine. On examination, the skin and mucous membranes were slate gray, especially on the face, neck, chest and upper extremities. The patient died from the disease 7 months after the initial diagnosis. Malignant melanoma is the most common malignancy to metastasize to the gastrointestinal tract, involving the small intestine, colon, stomach and esophagus [1 – 3]. The typical endoscopic finding is the " bullseye " or " target " lesions [1, 2]. As far as we know, this is the first described case of gastrointestinal melanosis associated with melanosis cutis, appearing in a patient with ultra-late recurrence of the disease [4, 5]. References 1 Reintgen DS, Thompson W, Garbutt J. Radiologic, endoscopic and surgical considerations of melanoma metastatic to the gastrointestinal tract: endoscopic experience. Morrison FS. Generalized melanosis complicating disseminated malignant melanoma in pregnancy: a case report.